产品名称 | iCRT5 - CRT Inhibitor iCRT5 |
产品货号 | Axon 2133 CAS [18623-44-4] MF C16H17NO5S2MW 367.44 Purity: 99% Soluble in DMSO Description Potent and cell-permeable β-catenin-responsive transcription (CRT) inhibitor, with IC50 value of 18 nM for Wnt responsive STF16 luciferase (STF16-Luc). iCRT5 acts by disrupting the interaction between β-catenin and TCF4, possibly by direct binding to β-catenin, while displaying minimal or less prominent effect on non-canonical Wnt signaling and other pathways such as Hh, JAK/STAT, and Notch signaling References Certificates Categories Extra info Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Stem Cell β-Catenin Wnt-β-Catenin Cell-Cell Adhesion Protein Wnt β-Catenin-responsive transcription (CRT) inhibitor Chemical name 4-(5-(3,4-dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid Parent CAS No. [18623-44-4] Order Size Unit Price Stock 10 mg €80.00 In Stock |
产品价格 | 现货询价,电话:010-67529703 |
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产品品牌 | axonmedchem |
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iCRT5 - CRT Inhibitor iCRT5Axon 2133 CAS [18623-44-4] MF C16H17NO5S2
Description
Potent and cell-permeable β-catenin-responsive transcription (CRT) inhibitor, with IC50 value of 18 nM for Wnt responsive STF16 luciferase (STF16-Luc). iCRT5 acts by disrupting the interaction between β-catenin and TCF4, possibly by direct binding to β-catenin, while displaying minimal or less prominent effect on non-canonical Wnt signaling and other pathways such as Hh, JAK/STAT, and Notch signaling
β-Catenin-responsive transcription (CRT) inhibitor
Chemical name4-(5-(3,4-dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid Parent CAS No.[18623-44-4] |
产品资料 |