产品名称 iCRT5 - CRT Inhibitor iCRT5
产品货号 Axon 2133 CAS [18623-44-4] MF C16H17NO5S2MW 367.44 Purity: 99% Soluble in DMSO Description Potent and cell-permeable β-catenin-responsive transcription (CRT) inhibitor, with IC50 value of 18 nM for Wnt responsive STF16 luciferase (STF16-Luc). iCRT5 acts by disrupting the interaction between β-catenin and TCF4, possibly by direct binding to β-catenin, while displaying minimal or less prominent effect on non-canonical Wnt signaling and other pathways such as Hh, JAK/STAT, and Notch signaling References Certificates Categories Extra info Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Stem Cell β-Catenin Wnt-β-Catenin Cell-Cell Adhesion Protein Wnt β-Catenin-responsive transcription (CRT) inhibitor Chemical name 4-(5-(3,4-dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid Parent CAS No. [18623-44-4] Order Size Unit Price Stock 10 mg €80.00 In Stock
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iCRT5 - CRT Inhibitor iCRT5

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2133

CAS [18623-44-4]

MF C16H17NO5S2
MW 367.44

  • Purity: 99%
  • Soluble in DMSO

iCRT5

Description

Potent and cell-permeable β-catenin-responsive transcription (CRT) inhibitor, with IC50 value of 18 nM for Wnt responsive STF16 luciferase (STF16-Luc). iCRT5 acts by disrupting the interaction between β-catenin and TCF4, possibly by direct binding to β-catenin, while displaying minimal or less prominent effect on non-canonical Wnt signaling and other pathways such as Hh, JAK/STAT, and Notch signaling
β-Catenin-responsive transcription (CRT) inhibitor

Chemical name

4-(5-(3,4-dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid

Parent CAS No.

[18623-44-4]

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