| 产品名称 | BIO - GSK-3 inhibitor IX | 6-Bromoindirubin-3'-oxime |
| 产品货号 | Axon 1693 CAS [667463-62-9] MF C16H10BrN3O2MW 356.17 Purity: 98% Soluble in DMSO Description Potent, reversible, ATP-competitive and selective inhibitor of glycogen synthase kinase GSK-3 (IC50: 5 nM); Inhibition of GSK by BIO results in the activation of the Wnt signaling pathway and sustained pluripotency in human and murine embryonic stem cells (ESCs). BIO is shown to maintain self-renewal in human and murine ESCs References Certificates Categories Extra info N Sato et al. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nature Med. 2004, 10(1), 55-63. L Meijer et al. GSK-3-selective inhibitors derived from tyrian purple indirubins. Chem. Biol. 2003, 10, 1255-1266. AS Tseng et al. The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Chem. Biol. 2006, 13, 957. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS Diabetes & Metabolism Immunology Pain & Inflammation Stem Cell GSK-3 Wnt-β-Catenin PI3K-Akt-mTOR EC 2.7.11.26 GSK-3 inhibitor Chemical name (Z)-6'-Bromo-1H,1'H-[2,3']biindolylidene-3,2'-dione 3-oxime Parent CAS No. [667463-62-9] Order Size Unit Price Stock 10 mg €95.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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BIO - GSK-3 inhibitor IX | 6-Bromoindirubin-3'-oximeAxon 1693 CAS [667463-62-9] MF C16H10BrN3O2
Description
Potent, reversible, ATP-competitive and selective inhibitor of glycogen synthase kinase GSK-3 (IC50: 5 nM); Inhibition of GSK by BIO results in the activation of the Wnt signaling pathway and sustained pluripotency in human and murine embryonic stem cells (ESCs). BIO is shown to maintain self-renewal in human and murine ESCs
GSK-3 inhibitor
Chemical name(Z)-6'-Bromo-1H,1'H-[2,3']biindolylidene-3,2'-dione 3-oxime Parent CAS No.[667463-62-9] |
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