GANT61 - NSC 136476

Based on 226 publications in PubMed 10 10 226

Axon 2642

CAS [500579-04-4]

MF C27H35N5
MW 429.60

Purity: 99%
Soluble in DMSO and Ethanol

GANT61

Description

Small molecule capable of reducing GLI-mediated transcription and endogenous Hedgehog (Hh) signaling (IC50 value ca 5 µM). In vivo, GANT61 suppressed human tumor cell growth until no tumor was palpable.

M Lauth et al. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8455-60.

BZ Stanton et al. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol. 2009 Mar;5(3):154-6.

R Zhang et al. Targeting GLI by GANT61 involves mechanisms dependent on inhibition of both transcription and DNA licensing. Oncotarget. 2016 Dec 6;7(49):80190-80207.

D Pan et al. Gli inhibitor GANT61 causes apoptosis in myeloid leukemia cells and acts in synergy with rapamycin. Leuk Res. 2012 Jun;36(6):742-8.

Inhibitor of GLI-mediated transcription and Hedgehog (Hh) signaling

Chemical name

2,2'-(2-(pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene)bis(N,N-dimethylaniline)

Parent CAS No.

[500579-04-4]

产品资料