KU 0060648

Based on 91 reference(s) in Google Scholar 9 10 91

Axon 2604

CAS [881375-00-4]

MF C33H34N4O4S
MW 582.71

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

KU 0060648

Description

Potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK), (IC50 = 8.6 nM); with 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases.

* The 3HCl salt of KU 0060648 (Axon 1584) used to be available as well, but is discontinued (Autumn 2016)

C Cano et al. 1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity. J Med Chem. 2013 Aug 22;56(16):6386-401.

J Bardos et al. Radio- and chemosensitization through inhibition of DNA-PK by KU-0060648. Mol. Cancer Ther. 2009, 8(12 Suppl), A116.

F Dumont et al. Radiosensitising agents for the radiotherapy of cancer: novel molecularly targeted approaches. Expert Opin. Ther. Pat. 2009, 19(6), 775-799.

JM Munck et al. Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K. Mol Cancer Ther. 2012 Aug;11(8):1789-98.

DNA-PK inhibitor

Chemical name

2-(4-Ethyl-piperazin-1-yl)-N-[4-(2-morpholin-4-yl-4-oxo-4H-chromen-8-yl)-dibenzothiophen-1-yl]-acetamide

Parent CAS No.

[881375-00-4]

产品资料