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产品名称 CAL 101 - Idelalisib
产品货号 Axon 2170 CAS [870281-82-6] MF C22H18FN7OMW 415.42 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Orally active and selective inhibitor of PI3K δ-isoform (IC50 p110δ: 2.5nM), displaying clinical activity in chronic lymphocytic leukemia (CLL). Cal 101 is 40- to 300-fold more selective for PI3K-δ (δ) isoform relative vs other PI3K class I enzymes (p110α, p110β, and p110γ IC50 were 820, 565, and 89nM, respectively). It does not promote apoptosis in normal T cells or natural killer cells, nor does it diminish antibody-dependent cellular cytotoxicity. References Certificates Categories Extra info S.E.M. Herman et al. Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood 2010, 116, 2078-2088.    J. Hoellenriegel et al. The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia. Blood 2011, 118, 3603-3612.  Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Pain & Inflammation PI3K PI3K-Akt-mTOR EC 2.7.1.153 PI3K inhibitor (p110 δ specific) Chemical name (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one Parent CAS No. [870281-82-6] Order Size Unit Price Stock 5 mg €95.00 In Stock
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CAL 101 - Idelalisib

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2170

CAS [870281-82-6]

MF C22H18FN7O
MW 415.42

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO

CAL 101

Description

Orally active and selective inhibitor of PI3K δ-isoform (IC50 p110δ: 2.5nM), displaying clinical activity in chronic lymphocytic leukemia (CLL). Cal 101 is 40- to 300-fold more selective for PI3K-δ (δ) isoform relative vs other PI3K class I enzymes (p110α, p110β, and p110γ IC50 were 820, 565, and 89nM, respectively). It does not promote apoptosis in normal T cells or natural killer cells, nor does it diminish antibody-dependent cellular cytotoxicity.
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