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产品名称 IC 87114
产品货号 Axon 2168 CAS [371242-69-2] MF C22H19N7OMW 397.43 Purity: 98% Soluble in DMSO Description Potent and highly selective small molecule inhibitor of the PI3K p110δ isoform (IC50 values for PI3Kα, β, γ, and δ are >100, 75, 29, and 0.5 μM respectively). IC87114 potently inhibited PIP3 biosynthesis in neutrophils by 60–65% and at 1 μM, it inhibited neutrophil migration by 75% as compared with the control.IC 87114 reduced the infiltration of inflammatory cells into the pancreatic islets and, accordingly, delayed and reduced the loss of glucose homeostasis. References Certificates Categories Extra info C. Sadhu et al. Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement. J. Immunol. 2003, 170, 2647-2654.    D.P. Sutherlin et al. Potent and selective inhibitors of PI3Kδ: obtaining isoform selectivity from the affinity pocket and tryptophan shelf. Bioorg. Med. Chem. Lett. 2012, 22, 4296-302.  Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Pain & Inflammation PI3K PI3K-Akt-mTOR EC 2.7.1.153 Potent and highly selective inhibitor of the PI3K p110δ Chemical name 2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one Parent CAS No. [371242-69-2] Order Size Unit Price Stock 5 mg €85.00 In Stock
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IC 87114

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2168

CAS [371242-69-2]

MF C22H19N7O
MW 397.43

  • Purity: 98%
  • Soluble in DMSO

IC 87114

Description

Potent and highly selective small molecule inhibitor of the PI3K p110δ isoform (IC50 values for PI3Kα, β, γ, and δ are >100, 75, 29, and 0.5 μM respectively). IC87114 potently inhibited PIP3 biosynthesis in neutrophils by 60–65% and at 1 μM, it inhibited neutrophil migration by 75% as compared with the control.IC 87114 reduced the infiltration of inflammatory cells into the pancreatic islets and, accordingly, delayed and reduced the loss of glucose homeostasis.
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