| 产品名称 | PF 477736 - PF 00477736 |
| 产品货号 | Axon 1379 CAS [952021-60-2] MF C22H25N7O2MW 419.48 Purity: 98% Optical purity: 99% ee Soluble in DMSO Description Chk1 inhibitor with Ki values of 0.49 and 47 nM for Chk1 and Chk2 respectively. A proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiation activity References Certificates Categories Extra info JW Janetka et al, Inhibitors of Checkpoint Kinases: From discovery to the clinic. Curr. Opin. Drug Discov. & Devel. 2007, 10(4), 473-486. S. Ashwell and S Zabludoff. DNA Damage Detection and Repair Pathways Recent Advances with Inhibitors of Checkpoint Kinases in Cancer Therapy. Clin. Cancer Res. 2008, 14(13), 4033-4037. Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology Stem Cell p53-Tumor Suppression DNA-damage Response EC 2.7.11.1 CHK Pfizer Licensed Products CHK1 inhibitor Chemical name (R)-2-Amino-2-cyclohexyl-N-[2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl]-acetamide Source information Pfizer compound; Sold for research purposes under agreement from Pfizer Inc. Parent CAS No. [952021-60-2] Order Size Unit Price Stock 2 mg €70.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
PF 477736 - PF 00477736Axon 1379 CAS [952021-60-2] MF C22H25N7O2
Description
Chk1 inhibitor with Ki values of 0.49 and 47 nM for Chk1 and Chk2 respectively. A proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiation activity
CHK1 inhibitor
Chemical name(R)-2-Amino-2-cyclohexyl-N-[2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl]-acetamide Source informationPfizer compound; Sold for research purposes under agreement from Pfizer Inc.Parent CAS No.[952021-60-2] |
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