| 产品名称 | GSK J1 |
| 产品货号 | Axon 1934 CAS [1373422-53-7] MF C22H23N5O2MW 389.45 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description The first selective and potent histone demethylase JMJD3/UTX inhibitor; blocks demethylation of histone H3K27; showed no activity against a panel of JMJ family demethylases and 100 protein kinases.Available also a cell permeable ethyl ester derivative GSK J4 (Axon 1933), which is a prodrug suitable for cell-based studies and will be hydrolyzed to GSK-J1 in cells rapidly References Certificates Categories Extra info L Kruidenier et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 2012, 488(7411), 404-408. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Epigenetics EC 1.14.11 Histone demethylase Histone demethylase JMJD3/UTX inhibitor Chemical name 3-(6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-ylamino)propanoic acid Parent CAS No. [1373422-53-7] Order Size Unit Price Stock 5 mg €105.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
GSK J1Axon 1934 CAS [1373422-53-7] MF C22H23N5O2
DescriptionThe first selective and potent histone demethylase JMJD3/UTX inhibitor; blocks demethylation of histone H3K27; showed no activity against a panel of JMJ family demethylases and 100 protein kinases.Available also a cell permeable ethyl ester derivative GSK J4 (Axon 1933), which is a prodrug suitable for cell-based studies and will be hydrolyzed to GSK-J1 in cells rapidly
Histone demethylase JMJD3/UTX inhibitor
Chemical name3-(6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-ylamino)propanoic acid Parent CAS No.[1373422-53-7] |
| 产品资料 |
