产品名称

LEE 011 - Ribociclib

产品货号

Axon 2273 CAS [1211441-98-3] MF C23H30N8OMW 434.54 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Orally bioavailable and highly selective small-molecule inhibitor of CDK4/6 (mean IC50 value 307 nM in sensitive neuroblastoma-derived cell lines). LEE011 caused cell-cycle arrest and cellular senescence that was attributed to dose-dependent decreases in phosphorylated RB and FOXM1, respectively. LEE 011 treatment of BE2C and IMR5 neuroblastoma cell lines with demonstrated sensitivity to CDK4/6 inhibition resulted in a dose-dependent accumulation of cells in the G0/G1 phase of the cell cycle. KEYWORDS: LEE 011 | supplier | CDK4/6 inhibitor | Ribociclib | LEE011 | LEE-011 | CAS [1211441-98-3] | Cyclin Dependent | CDK4 | CDK6 | orally bioavailable | cell-cycle arrest | senescence | FOXM1

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

LEE 011 - Ribociclib

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2273

CAS [1211441-98-3]

MF C23H30N8O
MW 434.54

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

LEE 011

Description

Orally bioavailable and highly selective small-molecule inhibitor of CDK4/6 (mean IC50 value 307 nM in sensitive neuroblastoma-derived cell lines). LEE011 caused cell-cycle arrest and cellular senescence that was attributed to dose-dependent decreases in phosphorylated RB and FOXM1, respectively. LEE 011 treatment of BE2C and IMR5 neuroblastoma cell lines with demonstrated sensitivity to CDK4/6 inhibition resulted in a dose-dependent accumulation of cells in the G0/G1 phase of the cell cycle.