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产品名称 R 547
产品货号 Axon 1983 CAS [741713-40-6] MF C18H21F2N5O4SMW 441.45 Purity: 99% Soluble in DMSO Description Potent and selective CDK inhibitor with Ki values to be 1, 3, 1 nM for CDK1, CDK2, and CDK4 respectively; inactive (Ki >5000 nM) against a panel of >120 unrelated kinases. R547 effectively inhibits proliferation of tumor cell lines independent of multidrug resistant status, histologic type, retinoblastoma protein, or p53 status, with IC50 values smaller or equal to 0.60 µM in vitro. References Certificates Categories Extra info XJ Chu et al. Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with (...). J. Med. Chem. 2006, 49(22), 6549-6560.    W DePinto et al. In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials. Mol. Cancer Ther. 2006, 5(11), 2644-2658.  Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology p53-Tumor Suppression EC 2.7.11.22 CDK CDK inhibitor (1, 2, and 4 specific) Chemical name (4-amino-2-(1-(methylsulfonyl)piperidin-4-ylamino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone Parent CAS No. [741713-40-6] Order Size Unit Price Stock 5 mg €95.00 In Stock
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R 547

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1983

CAS [741713-40-6]

MF C18H21F2N5O4S
MW 441.45

  • Purity: 99%
  • Soluble in DMSO

R 547

Description

Potent and selective CDK inhibitor with Ki values to be 1, 3, 1 nM for CDK1, CDK2, and CDK4 respectively; inactive (Ki >5000 nM) against a panel of >120 unrelated kinases. R547 effectively inhibits proliferation of tumor cell lines independent of multidrug resistant status, histologic type, retinoblastoma protein, or p53 status, with IC50 values smaller or equal to 0.60 µM in vitro.
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