产品名称

EED226

产品货号

Axon 2701 CAS [2083627-02-3] MF C17H15N5O3SMW 369.40 Purity: 99% Soluble in DMSO Description EED226 is a first-in-class, potent, selective and orally bioavailable PRC2 inhibitor (IC50 values of 23.4 nM and 53.5 nM with H3K27me0 peptide and the mononucleosome as the substrates, respectively) that directly binds to the H3K27me3 binding pocket of EED. EED226 effectively induced tumor regression in a mouse xenograft model. KEYWORDS: EED226 | supplier | PRC2 inhibitor | EED-226 | EED 226 | CAS [2083627-02-3] | PRC | Inhibitor | Proteins | EED | PRC | EZH1 | EZH2

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

EED226

Based on 4 reference(s) in Google Scholar 8 10 4

Axon 2701

CAS [2083627-02-3]

MF C17H15N5O3S
MW 369.40

Purity: 99%
Soluble in DMSO

EED226

Description

EED226 is a first-in-class, potent, selective and orally bioavailable PRC2 inhibitor (IC50 values of 23.4 nM and 53.5 nM with H3K27me0 peptide and the mononucleosome as the substrates, respectively) that directly binds to the H3K27me3 binding pocket of EED. EED226 effectively induced tumor regression in a mouse xenograft model.

KEYWORDS: EED226 | supplier | PRC2 inhibitor | EED-226 | EED 226 | CAS [2083627-02-3] | PRC | Inhibitor | Proteins | EED | PRC | EZH1 | EZH2

Y Huang et al. Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy. J Med Chem. 2017 Mar 23;60(6):2215-2226.

W Qi et al. An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED. Nat Chem Biol. 2017 Apr;13(4):381-388.

Potent, selective and orally bioavailable PRC2 inhibitor

Chemical name

N-(Furan-2-ylmethyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine

Parent CAS No.

[2083627-02-3]

产品资料