| 产品名称 | AZD 5438 |
| 产品货号 | Axon 1966 CAS [602306-29-6] MF C18H21N5O2SMW 371.46 Purity: 99% Soluble in DMSO Description Potent and orally bioavailable inhibitor of cyclin-dependent kinase (cdk) 1, 2, and 9 (IC50: 16, 6, and 20 nM, respectively); AZD5438 showed significant antiproliferative activity in human tumor cell lines (IC50: 0.2-1.7 mM) References Certificates Categories Extra info KF Byth et al. AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. Mol. Cancer Ther. 2009, 8(7), 1856-1866. DS Boss et al. Safety, tolerability, pharmacokinetics and pharmacodynamics of the oral cyclin-dependent kinase inhibitor AZD5438 when administered at intermittent and continuous dosing schedules in patients (...). Ann. Oncol. 2010, 21(4), 884-894. Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology p53-Tumor Suppression EC 2.7.11.22 CDK CDK inhibitor (1, 2, and 9 specific) Chemical name 4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine Parent CAS No. [602306-29-6] Order Size Unit Price Stock 5 mg €80.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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AZD 5438Axon 1966 CAS [602306-29-6] MF C18H21N5O2S
Description
Potent and orally bioavailable inhibitor of cyclin-dependent kinase (cdk) 1, 2, and 9 (IC50: 16, 6, and 20 nM, respectively); AZD5438 showed significant antiproliferative activity in human tumor cell lines (IC50: 0.2-1.7 mM)
CDK inhibitor (1, 2, and 9 specific)
Chemical name4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine Parent CAS No.[602306-29-6] |
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