产品名称

TC Mps1 12

产品货号

Axon 2755 CAS [1206170-62-8] MF C17H20N6OMW 324.38 Purity: 99% Soluble in DMSO Description Potent and selective Mps1 (TTK) kinase inhibitor (IC50 value of 6.4 nM) with good cellular activity, pharmacokinetic properties and efficacy in the A549 lung cancer xenograft model. Additionally, TC Mps1 12 suppressed the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability. KEYWORDS: TC Mps1 12 | supplier | Mps1 inhibitor | CAS [1206170-62-8] | Non Selective (Mitotic Spindle Checkpoint) | MPS1 Kinase | Inhibitor | Enzymes | TTK

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

TC Mps1 12

Based on 4 reference(s) in Google Scholar 8 10 4

Axon 2755

CAS [1206170-62-8]

MF C17H20N6O
MW 324.38

Purity: 99%
Soluble in DMSO

TC Mps1 12

Description

Potent and selective Mps1 (TTK) kinase inhibitor (IC50 value of 6.4 nM) with good cellular activity, pharmacokinetic properties and efficacy in the A549 lung cancer xenograft model. Additionally, TC Mps1 12 suppressed the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability.

K Ken-ichi et al. Diaminopyridine-Based Potent and Selective Mps1 Kinase Inhibitors Binding to an Unusual Flipped-Peptide Conformation. ACS Med Chem Lett. 2012 Jul 12; 3(7): 560–564.

M Choi et al. TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability. Br J Pharmacol. 2017 Jun;174(12):1810-1825.

Potent and selective inhibitor of MPS1 kinase

Chemical name

4-(4-Amino-6-(tert-butylamino)-5-cyanopyridin-2-ylamino)benzamide

Parent CAS No.

[1206170-62-8]

产品资料