产品名称 XL 019
产品货号 Axon 2231 CAS [945755-56-6] MF C25H28N6O2MW 444.53 Purity: 99% Optical purity: Optically pure Soluble in 0.1N HCl(aq) and DMSO Description Potent, selective, and orally active JAK2 inhibitor (IC50 values 2.2 nM and 214.2 nM for JAK2 and JAK3 respectively), showing a significant dose-dependent pharmacodynamic and antitumor effect in a mouse xenograft model. XL 019 significantly inhibits downstream markers pSTAT1 and pSTAT3 (ED50 values 42 mg/kg pSTAT1, and 210 mg/kg pSTAT3). References Certificates Categories Extra info S. Verstovsek et al. Phase I evaluation of XL019, an oral, potent, and selective JAK2 inhibitor. Leuk. Res. 2014, 38, 316-322.   T. Forsyth et al. SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors. Bioorg. Med. Chem. Lett. 2012, 22, 7653-7658. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Epigenetics JAK-STAT EC 2.7.10.2 JAK JAK2 inhibitor Chemical name (S)-N-(4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)phenyl)pyrrolidine-2-carboxamide Parent CAS No. [945755-56-6] Order Size Unit Price Stock 5 mg €100.00 In Stock
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XL 019

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2231

CAS [945755-56-6]

MF C25H28N6O2
MW 444.53

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in 0.1N HCl(aq) and DMSO

XL 019

Description

Potent, selective, and orally active JAK2 inhibitor (IC50 values 2.2 nM and 214.2 nM for JAK2 and JAK3 respectively), showing a significant dose-dependent pharmacodynamic and antitumor effect in a mouse xenograft model. XL 019 significantly inhibits downstream markers pSTAT1 and pSTAT3 (ED50 values 42 mg/kg pSTAT1, and 210 mg/kg pSTAT3).
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