| 产品名称 | Stattic |
| 产品货号 | Axon 2314 CAS [19983-44-9] MF C8H5NO4SMW 211.19 Purity: 99% Soluble in DMSO Description The first nonpeptidic small-molecule inhibitor of STAT3 activation, dimerization, and nuclear translocation (IC50 value 5.1 μM for inhibition of the binding of a phosphotyrosine-containing peptide derived from the gp130 receptor to the STAT3 SH2 domain). Stattic demonstrates good selectivity for STAT3 inhibition over STAT1, and increases the apoptotic rate of STAT3-dependent breast cancer cell lines. References Certificates Categories Extra info H. Chen et al. Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). Eur. J. Med. Chem. 2014, 82, 195-203. J. Schust et al. Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem. Biol. 2006, 11, 1235-1242. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology Immunology Stem Cell Transcription Factors JAK-STAT TF class 4.2.1 STAT3 Nonpeptidic small-molecule inhibitor of STAT3 activation, dimerization, and nuclear translocation Chemical name 6-nitroBenzo[b]thiophene-1,1-dioxide Parent CAS No. [19983-44-9] Order Size Unit Price Stock 10 mg €50.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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StatticAxon 2314 CAS [19983-44-9] MF C8H5NO4S
Description
The first nonpeptidic small-molecule inhibitor of STAT3 activation, dimerization, and nuclear translocation (IC50 value 5.1 μM for inhibition of the binding of a phosphotyrosine-containing peptide derived from the gp130 receptor to the STAT3 SH2 domain). Stattic demonstrates good selectivity for STAT3 inhibition over STAT1, and increases the apoptotic rate of STAT3-dependent breast cancer cell lines.
Nonpeptidic small-molecule inhibitor of STAT3 activation, dimerization, and nuclear translocation
Chemical name6-nitroBenzo[b]thiophene-1,1-dioxide Parent CAS No.[19983-44-9] |
| 产品资料 |
