产品名称

Amcasertib - BBI503

产品货号

Axon 2971 CAS [1129403-56-0] MF C31H33N5O2SMW 539.69 Purity: 98% Soluble in DMSO Recently added

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Amcasertib - BBI503

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2971

CAS [1129403-56-0]

MF C31H33N5O2S
MW 539.69

Purity: 98%
Soluble in DMSO

Recently added

Amcasertib

Description

Amcasertib is a first-in-class cancer stemness kinase inhibitor with potent in vitro and in vivo activity against cancer stem cells (CSC). By targeting multiple serine-threonine stemness kinases, amcasertib inhibits Nanog and other cancer stemness pathways.

DJ Jonker et al. Phase 1 extension study of BBI503, a first-in-class cancer stemness kinase inhibitor, in patients with advanced colorectal cancer. Journal of Clinical Oncology 33, no. 15_suppl (May 20 2015) 3615-3615.

GM Cote et al. A phase 1b/2 study of amcasertib, a first-in-class cancer stemness kinase inhibitor, in advanced adenoid cystic carcinoma. Journal of Clinical Oncology 35, no. 15_suppl (May 20 2017) 6036-6036.

First-in-class stemness kinase inhibitor

Chemical name

N-(2-(Diethylamino)ethyl)-2,4-dimethyl-5-((2-oxo-5-(2-phenylthiazol-4-yl)indolin-3-ylidene)methyl)-1H-pyrrole-3-carboxamide

Parent CAS No.

[1129403-56-0]

产品资料