产品名称

AS 1517499

产品货号

Axon 1992 CAS [919486-40-1] MF C20H20ClN5O2MW 397.86 Purity: 99% Soluble in DMSO Description Potent and selective STAT6 inhibitor (IC50: 21 nM) KEYWORDS: AS 1517499 | supplier | STAT6 inhibitor | AS1517499 | AS-1517499 | CAS [919486-40-1] | DNA-RNA | STAT6 | Inhibitor | Transcription Factor | NF-κB | IL-13 | TNF-α | asthma | interleukin

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

AS 1517499

Based on 95 reference(s) in Google Scholar 10 10 95

Axon 1992

CAS [919486-40-1]

MF C20H20ClN5O2
MW 397.86

Purity: 99%
Soluble in DMSO

AS 1517499

Description

Potent and selective STAT6 inhibitor (IC50: 21 nM)

KEYWORDS: AS 1517499 | supplier | STAT6 inhibitor | AS1517499 | AS-1517499 | CAS [919486-40-1] | DNA-RNA | STAT6 | Inhibitor | Transcription Factor | NF-κB | IL-13 | TNF-α | asthma | interleukin

S Nagashima et al. Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors. Bioorg. Med. Chem. 2007, 15(2), 1044-1055.

Y Chiba et al. A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice. Am. J. Respir. Cell Mol. Biol. 2009, 41(5), 516-524.

K Goto et al. The proximal STAT6 and NF-κB sites are responsible for IL-13- and TNF-α-induced RhoA transcriptions in human bronchial smooth muscle cells. Pharmacol. Res. 2010, 61(5), 466–472.

List of publications using AS 1517499 (Axon 1992) purchased from Axon Medchem

Cell Signaling & Oncology Immunology Stem Cell STAT6 Transcription Factors JAK-STAT TF class 4.2.1

Potent and selective STAT6 inhibitor

Chemical name

4-(benzylamino)-2-(3-chloro-4-hydroxyphenethylamino)pyrimidine-5-carboxamide

Parent CAS No.

[919486-40-1]

产品资料