产品名称

INCB 024360 - Epacadostat

产品货号

Axon 1733 CAS [1204669-58-8] MF C11H13BrFN7O4SMW 438.23 Purity: 98% Soluble in DMSO Description Potent competitive inhibitor of indoleamine 2,3-dioxygenase (IDO1, IC50 value 72 nM in vitro) with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model; INCB024360 (Epacadostat) decreased kynurenine levels by >50% in plasma and inhibited B16-GM-CSF tumor growth in a dose dependent fashion. An analog of INCB 024360 (Axon 2215) is available as well. KEYWORDS: INCB 24360 | IDO1 inhibitor | Axon 1733 | Epacadostat | INCB 024360 | INCB024360 | INCB24360 | CAS [1204669-58-8] | [1204669-37-3] | Kynurenine | cancer | immunotherapy | melanoma | hydroxamidine

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

INCB 024360 - Epacadostat

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1733

CAS [1204669-58-8]

MF C11H13BrFN7O4S
MW 438.23

Purity: 98%
Soluble in DMSO

INCB 024360

Description

Potent competitive inhibitor of indoleamine 2,3-dioxygenase (IDO1, IC50 value 72 nM in vitro) with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model; INCB024360 (Epacadostat) decreased kynurenine levels by >50% in plasma and inhibited B16-GM-CSF tumor growth in a dose dependent fashion.

An analog of INCB 024360 (Axon 2215) is available as well.

C. Sheridan. IDO inhibitors move center stage in immuno-oncology. Nat Biotechnol. 2015 Apr;33(4):321-2.

U.F. Röhrig et al. Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors. J Med Chem. 2015 May 26.

X. Liu et al. Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity. Blood. 2010 Apr 29;115(17):3520-30.

Apoptosis Cell Signaling & Oncology CNS Immunology Pain & Inflammation IDO1 EC 1.13.11.52

Potent inhibitor of indoleamine 2,3-dioxygenase-1 (IDO1)

Chemical name

(Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-(2-(sulfamoylamino)ethylamino)-1,2,5-oxadiazole-3-carboximidamide

Parent CAS No.

[1204669-58-8]

产品资料