| 产品名称 | Ruxolitinib - INCB 018424 phosphate |
| 产品货号 | Axon 1598 CAS [1092939-17-7] MF C17H18N6.H3O4PMW 404.36 Purity: 99% Optical purity: 98% ee Soluble in water and DMSO Description An orally bioavailable, potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively; selectivity >100 fold for a wide range of other kinases. It acts by blocking the JAK/STAT pathway References Certificates Categories Extra info RA Mesa. Ruxolitinib, a selective JAK1 and JAK2 inhibitor for the treatment of myeloproliferative neoplasms and psoriasis. IDrugs. 2010, 13(6), 394-403. C Campas-Moya. Ruxolitinib. Drugs Fut. 2010, 35(6), 457. S Verstovsek et al. Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. N. Engl. J. Med. 2010, 363(12), 1117-1127. A Quintas-Cardama et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood 2010, 115(15), 3109-3117. E Apostolidou et al. JAK2 inhibitors: a reality? a hope? Clin. Lymp Myel. 2009, 9(Suppl. 3), S340-S345. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Epigenetics JAK-STAT EC 2.7.10.2 JAK JAK1 and JAK2 inhibitor Chemical name (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate Parent CAS No. [941678-49-5] Order Size Unit Price Stock 2 mg €70.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
Ruxolitinib - INCB 018424 phosphateAxon 1598 CAS [1092939-17-7] MF C17H18N6.H3O4P
Description
An orally bioavailable, potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively; selectivity >100 fold for a wide range of other kinases. It acts by blocking the JAK/STAT pathway
JAK1 and JAK2 inhibitor
Chemical name(R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate Parent CAS No.[941678-49-5] |
| 产品资料 |
