产品名称

Gisadenafil besylate - UK 369003 | PF 01224715

产品货号

Axon 2218 CAS [334827-98-4] MF C22H31N7O5S.C7H8O3SMW 677.79 Purity: 99% Soluble in water and DMSO Description Potent and selective inhibitor of cGMP-specific PDE5 (IC50 value 1.23 nM) with improved selectivity over PDE6 (PDE5/6 selectivity value 117 and >3000-fold selectivity over other PDEs). Gisadenafil has the potential for oral bioavailability and dose-proportional pharmacokinetics. Close analogue of Sildenafil (Viagra; Axon 2046) References Certificates Categories Extra info D.J. Rawson et al. The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics. Bioorg. Med. Chem. 2012, 20, 498-509. N.A.M. Tamimi et al. A placebo-controlled study investigating the efficacy and safety of the phosphodiesterase type 5 inhibitor UK-369,003 for the treatment of men with lower urinary tract symptoms associated (...). BJU Int. 2010, 106, 674–680. Certificate of Analysis Material Safety Data Sheet Cardiovascular Cell Signaling & Oncology CNS Immunology EC 3.1.4.35 PDE Pfizer Licensed Products Potent and selective inhibitor of PDE5 Chemical name 5-(2-ethoxy-5-(4-ethylpiperazin-1-ylsulfonyl)pyridin-3-yl)-3-ethyl-2-(2-methoxyethyl)-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one benzenesulfonate Source information Pfizer compound; Sold for research purposes under agreement from Pfizer Inc. Parent CAS No. [334826-98-1] Order Size Unit Price Stock 10 mg €105.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Gisadenafil besylate - UK 369003 | PF 01224715

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2218

CAS [334827-98-4]

MF C22H31N7O5S.C7H8O3S
MW 677.79

Purity: 99%
Soluble in water and DMSO

Gisadenafil besylate

Description

Potent and selective inhibitor of cGMP-specific PDE5 (IC50 value 1.23 nM) with improved selectivity over PDE6 (PDE5/6 selectivity value 117 and >3000-fold selectivity over other PDEs). Gisadenafil has the potential for oral bioavailability and dose-proportional pharmacokinetics.

Close analogue of Sildenafil (Viagra; Axon 2046)

D.J. Rawson et al. The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics. Bioorg. Med. Chem. 2012, 20, 498-509.

N.A.M. Tamimi et al. A placebo-controlled study investigating the efficacy and safety of the phosphodiesterase type 5 inhibitor UK-369,003 for the treatment of men with lower urinary tract symptoms associated (...). BJU Int. 2010, 106, 674–680.

Cardiovascular Cell Signaling & Oncology CNS Immunology EC 3.1.4.35 PDE Pfizer Licensed Products

Potent and selective inhibitor of PDE5

Chemical name

5-(2-ethoxy-5-(4-ethylpiperazin-1-ylsulfonyl)pyridin-3-yl)-3-ethyl-2-(2-methoxyethyl)-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one benzenesulfonate

Source information

Pfizer compound; Sold for research purposes under agreement from Pfizer Inc.

Parent CAS No.

[334826-98-1]

产品资料