产品名称

CGP 77675

产品货号

Axon 2097 CAS [234772-64-6] MF C26H29N5O2MW 443.54 Purity: 98% Soluble in 0.1N HCl(aq) and DMSO Description Potent and selective Src family kinase (SFK) inhibitor; CGP77675 inhibited phosphorylation of peptide substrates and autophosphorylation of purified Src (IC50: 5-20 and 40 nM, respectively). The dual inhibition of Src and GSK-3 signaling by CGP 77675 and CHIR 99021 (termed alternative 2i, Axon 2130) was found to maintain mouse embryonic stem cell (mESC) self-renewal and pluripotency marker expression as efficiently as the dual inhibition of MAPK and GSK-3 by PD 0325901 and CHIR 99021 (conventional 2i, Axon 2128). This alternative 2i method provides a versatile tool not only for the maintenance of mESCs in serum-free conditions but also for the derivation of ESCs from mouse embryos. *Promotion

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axonmedchem

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CGP 77675

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2097

CAS [234772-64-6]

MF C26H29N5O2
MW 443.54

Purity: 98%
Soluble in 0.1N HCl(aq) and DMSO

CGP 77675

Description

Potent and selective Src family kinase (SFK) inhibitor; CGP77675 inhibited phosphorylation of peptide substrates and autophosphorylation of purified Src (IC50: 5-20 and 40 nM, respectively). The dual inhibition of Src and GSK-3 signaling by CGP 77675 and CHIR 99021 (termed alternative 2i, Axon 2130) was found to maintain mouse embryonic stem cell (mESC) self-renewal and pluripotency marker expression as efficiently as the dual inhibition of MAPK and GSK-3 by PD 0325901 and CHIR 99021 (conventional 2i, Axon 2128). This alternative 2i method provides a versatile tool not only for the maintenance of mESCs in serum-free conditions but also for the derivation of ESCs from mouse embryos.

*Promotion: CGP 77675 is also part of Inhibitor Set(s):

Axon 2130

M Missbach et al. A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivo. Bone. 1999, 24(5), 437-449.

T Shimizu et al. Dual inhibition of Src and GSK3 maintains mouse embryonic stem cells, whose differentiation is mechanically regulated by Src signaling. Stem Cells 2012, 30(7), 1394-1404.

Src Family kinase (SFK) inhibitor

Chemical name

1-(amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenethyl)piperidin-4-ol

Parent CAS No.

[234772-64-6]

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