产品名称

STAT5 Inhibitor 1 [285986-31-4]

产品货号

Axon 2731 CAS [285986-31-4] MF C16H11N3O3MW 293.28 Purity: 98% Soluble in DMSO Description STAT5 Inhibitor 1 [285986-31-4] is a first nonpeptidic small-molecule which selectively inhibits the function of the STAT5b domain (IC50 value of 47 μM), STAT5 DNA binding in vitro, and activation of STAT5 in a cancer cell line. Also selective impairment of STAT5 phosphorylation with STAT5 Inhibitor 1 markedly reduced iTregs. KEYWORDS: STAT5 Inhibitor 1 [285986-31-4] | supplier | STAT5 inhibitor | CAS [285986-31-4] | DNA-RNA | STAT5 | Inhibitor | Transcription Factors | CAS [1187749-60-5] | STAT5b | iTreg

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

STAT5 Inhibitor 1 [285986-31-4]

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2731

CAS [285986-31-4]

MF C16H11N3O3
MW 293.28

Purity: 98%
Soluble in DMSO

STAT5 Inhibitor 1 [285986-31-4]

Description

STAT5 Inhibitor 1 [285986-31-4] is a first nonpeptidic small-molecule which selectively inhibits the function of the STAT5b domain (IC50 value of 47 μM), STAT5 DNA binding in vitro, and activation of STAT5 in a cancer cell line. Also selective impairment of STAT5 phosphorylation with STAT5 Inhibitor 1 markedly reduced iTregs.

J Müller et al. Discovery of chromone-based inhibitors of the transcription factor STAT5. Chembiochem. 2008 Mar 25;9(5):723-7.

BC Betts et al. STAT5 polarization promotes iTregs and suppresses human T-cell alloresponses while preserving CTL capacity. J Leukoc Biol. 2014 Feb;95(2):205-13.

Apoptosis Cell Signaling & Oncology Immunology Transcription Factors JAK-STAT TF class 4.2.1 STAT5

Nonpeptidic small-molecule inhibitor of STAT5 activation

Chemical name

N'-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide

Parent CAS No.

[285986-31-4]

产品资料