产品名称

NG 25 trihydrochloride

产品货号

Axon 2366 CAS [2108554-00-1] MF C29H30F3N5O2.3HClMW 646.96 Purity: 98% Soluble in water and DMSO Description Type II inhibitor of TAK1 (MAP3K7) and MAP4K2 (GCK) with nanomolar potency for a wider range of kinases (IC50 values 13 nM, 22 nM, 56 nM, 75 nM, 82 nM, 102 nM, 113 nM, and 149 nM for LYN, MAP4K2, CSK, Abl, FER, p38α, SRC, and TAK1, repectively). At 0.1 µM NG25 shows strong inhibition of TAK1, Lck, MAP4K2, p38α, Abl, YES1, and OSR1. NG 25 potently inhibited the activation of IKKβ by TLR7 and TLR9 agonists and prevented the secretion of type 1 IFNs induced by these ligands in Gen2.2 cells. KEYWORDS: NG 25 trihydrochloride | supplier | TAK1 (MAP3K7) and MAP4K2 inhibitor | NG25 | CAS [2108554-00-1] | [1315355-93-1] | MAPK | MAP3K | MAP4K | Lck | RAF | ERK | IKKβ | LYN | CSK | Abl | FER | p38α | SRC | NF-kappaB | TNF | Interferon | Immunology | PDC | Toll like | TLR | Inhibitor | Enzymes

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

NG 25 trihydrochloride

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2366

CAS [2108554-00-1]

MF C29H30F3N5O2.3HCl
MW 646.96

Purity: 98%
Soluble in water and DMSO

NG 25 trihydrochloride

Description

Type II inhibitor of TAK1 (MAP3K7) and MAP4K2 (GCK) with nanomolar potency for a wider range of kinases (IC50 values 13 nM, 22 nM, 56 nM, 75 nM, 82 nM, 102 nM, 113 nM, and 149 nM for LYN, MAP4K2, CSK, Abl, FER, p38α, SRC, and TAK1, repectively). At 0.1 µM NG25 shows strong inhibition of TAK1, Lck, MAP4K2, p38α, Abl, YES1, and OSR1. NG 25 potently inhibited the activation of IKKβ by TLR7 and TLR9 agonists and prevented the secretion of type 1 IFNs induced by these ligands in Gen2.2 cells.

KEYWORDS: NG 25 trihydrochloride | supplier | TAK1 (MAP3K7) and MAP4K2 inhibitor | NG25 | CAS [2108554-00-1] | [1315355-93-1] | MAPK | MAP3K | MAP4K | Lck | RAF | ERK | IKKβ | LYN | CSK | Abl | FER | p38α | SRC | NF-kappaB | TNF | Interferon | Immunology | PDC | Toll like | TLR | Inhibitor | Enzymes