产品名称

Motolimod - VTX-2337 | VTX-378

产品货号

Axon 2783 CAS [926927-61-9] MF C28H34N4O2MW 458.60 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Motolimod is a highly potent and selective TLR8 agonist (EC50 value of 100 nM). Motolimod directly activates myeloid dendritic cells, monocytes, and NK cells, resulting in the production of high levels of mediators including: TNFα, IL-12, and IFNγ, known to orchestrate adaptive antitumor responses. KEYWORDS: Motolimod | supplier | TLR8 agonist | VTX-2337 | VTX-378 | VTX 2337 | VTX2337 | VTX 378 | VTX378 | CAS [926927-61-9] | DNA-RNA | TLR8 | Agonist | Receptors | Antitumor

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Motolimod - VTX-2337 | VTX-378

Based on 16 reference(s) in Google Scholar 8 10 16

Axon 2783

CAS [926927-61-9]

MF C28H34N4O2
MW 458.60

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

Motolimod

Description

Motolimod is a highly potent and selective TLR8 agonist (EC50 value of 100 nM). Motolimod directly activates myeloid dendritic cells, monocytes, and NK cells, resulting in the production of high levels of mediators including: TNFα, IL-12, and IFNγ, known to orchestrate adaptive antitumor responses.

KEYWORDS: Motolimod | supplier | TLR8 agonist | VTX-2337 | VTX-378 | VTX 2337 | VTX2337 | VTX 378 | VTX378 | CAS [926927-61-9] | DNA-RNA | TLR8 | Agonist | Receptors | Antitumor

H Lu et al. VTX-2337 is a novel TLR8 agonist that activates NK cells and augments ADCC. Clin Cancer Res. 2012 Jan 15;18(2):499-509.

Highly potent and selective TLR8 agonist

Chemical name

(1E,4E)-2-Amino-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

Parent CAS No.

[926927-61-9]

产品资料