产品名称

Selexipag - NS 304 | ACT 293987 | Uptravi

产品货号

Axon 2605 CAS [475086-01-2] MF C26H32N4O4SMW 496.62 Purity: 100% Soluble in DMSO Description Orally available and long-acting prodrug of MRE 269, a potent and highly selective IP receptor agonist (Ki values 20 nM and 260 nM for inhibition of [3H]iloprost binding to human IP receptor by MRE 269 and Selexipag, respectively). Capable of ameliorating vascular endothelial dysfunction, pulmonary arterial wall hypertrophy, and right ventricular hypertrophy. Furthermore, Selexipag (NS 304) elevated right ventricular systolic pressure and improved survival in a rat model of pulmonary hypertension induced by monocrotaline (MCT). KEYWORDS: Selexipag | supplier | IP agonist prodrug | NS 304 | ACT 293987 | NS304 | ACT293987 | CAS [475086-01-2] - [1267423-51-7] | Prostaglandins | PGI2 (IP) | Agonist | MRE269 | prodrug | prostacyclin | PGI2 | pulmonary | hypertension | vascular | endothelial | dysfunction | hypertrophy

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Selexipag - NS 304 | ACT 293987 | Uptravi

Based on 38 publications in PubMed 9 10 38

Axon 2605

CAS [475086-01-2]

MF C26H32N4O4S
MW 496.62

Purity: 100%
Soluble in DMSO

Selexipag

Description

Orally available and long-acting prodrug of MRE 269, a potent and highly selective IP receptor agonist (Ki values 20 nM and 260 nM for inhibition of [3H]iloprost binding to human IP receptor by MRE 269 and Selexipag, respectively). Capable of ameliorating vascular endothelial dysfunction, pulmonary arterial wall hypertrophy, and right ventricular hypertrophy. Furthermore, Selexipag (NS 304) elevated right ventricular systolic pressure and improved survival in a rat model of pulmonary hypertension induced by monocrotaline (MCT).

KEYWORDS: Selexipag | supplier | IP agonist prodrug | NS 304 | ACT 293987 | NS304 | ACT293987 | CAS [475086-01-2] - [1267423-51-7] | Prostaglandins | PGI2 (IP) | Agonist | MRE269 | prodrug | prostacyclin | PGI2 | pulmonary | hypertension | vascular | endothelial | dysfunction | hypertrophy

K Kuwano et al. 2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug. J Pharmacol Exp Ther. 2007 Sep;322(3):1181-8.

K Kuwano et al. A long-acting and highly selective prostacyclin receptor agonist prodrug, NS-304, ameliorates rat pulmonary hypertension with unique relaxant responses of its active form.... J Pharmacol Exp Ther. 2008 Sep;326(3):691-9.

G Simonneau et al. Selexipag: an oral, selective prostacyclin receptor agonist for the treatment of pulmonary arterial hypertension. Eur Respir J. 2012 Oct;40(4):874-80.

Cardiovascular Immunology Pain & Inflammation A14 PGI2 (IP)

Prodrug of MRE 269, a potent IP receptor (PGI2) agonist

Chemical name

2-(4-((5,6-diphenylpyrazin-2-yl)(isopropyl)amino)butoxy)-N-(methylsulfonyl)acetamide

Parent CAS No.

[475086-01-2]

产品资料