KO 143

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 1409

CAS [461054-93-3]

MF C26H35N3O5
MW 469.57

Purity: 99%
Soluble in DMSO and Ethanol

KO 143

Description

Potent and selective inhibitor of breast cancer resistance protein (BCRP) multidrug transporter.

JD Allen et al. Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C. Mol Cancer Ther. 2002 Apr;1(6):417-25.

A van Loevezijn et al. Inhibition of BCRP-mediated drug efflux by fumitremorgin-type indolyl diketopiperazines. Bioorg Med Chem Lett. 2001 Jan 8;11(1):29-32.

BCRP inhibitor

Chemical name

3-((3S,6S,12aS)-6-Isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)-propionic acid tert-butylester

Parent CAS No.

[461054-93-3]

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