产品名称

AZD 7762 hydrochloride

产品货号

Axon 1399 CAS [860352-01-8] MF C17H19FN4O2S.HClMW 398.88 Purity: 99% Optical purity: >98% ee Soluble in water and DMSO Description Potent and selective inhibitor of checkpoint kinase (CHK; IC50 values 5 nM for Chk1/Chk2). KEYWORDS: AZD 7762 hydrochloride | supplier | CHK inhibitor | AZD7762 HCl | AZD-7762 | CAS [860352-01-8] | DNA-RNA | checkpoint kinase | CHK1 | CHK2 | stem cell | hematopoetic | HCS

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

AZD 7762 hydrochloride

Based on 275 publications in PubMed 9 10 275

Axon 1399

CAS [860352-01-8]

MF C17H19FN4O2S.HCl
MW 398.88

Purity: 99%
Optical purity: >98% ee
Soluble in water and DMSO

AZD 7762 hydrochloride

Description

Potent and selective inhibitor of checkpoint kinase (CHK; IC50 values 5 nM for Chk1/Chk2).

KEYWORDS: AZD 7762 hydrochloride | supplier | CHK inhibitor | AZD7762 HCl | AZD-7762 | CAS [860352-01-8] | DNA-RNA | checkpoint kinase | CHK1 | CHK2 | stem cell | hematopoetic | HCS

JW Janetka et al, Inhibitors of Checkpoint Kinases: From discovery to the clinic. Curr. Opin. Drug Discov. & Devel. 2007, 10(4), 473-486.

S. Ashwell and S Zabludoff. DNA Damage Detection and Repair Pathways Recent Advances with Inhibitors of Checkpoint Kinases in Cancer Therapy. Clin. Cancer Res. 2008, 14(13), 4033-4037.

SD Zabludoff et al. AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Mol. Cancer Ther. 2008, 7(9), 2955-2966.

L Carrassa et al. Role of Chk1 in the differentiation program of hematopoietic stem cells. Cell. Mol. Life Sci. 2010, 67, 1713–1722.

List of publications using AZD 7762 (Axon 1399) purchased from Axon Medchem

Cell Cycle Regulation Cell Signaling & Oncology Stem Cell p53-Tumor Suppression DNA-damage Response EC 2.7.11.1 CHK

CHK inhibitor

Chemical name

5-(3-Fluoro-phenyl)-3-ureido-thiophene-2-carboxylic acid (S)-piperidin-3-ylamide hydrochloride

Parent CAS No.

[860352-01-8]

产品资料