产品名称

TIC 10 active isomer - Angular TIC 10 | Active isomer 2

产品货号

Axon 2300 CAS [1616632-77-9] MF C24H26N4OMW 386.49 Purity: 99% Soluble in DMSO Description Potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner. TIC10/ONC201 inactivates kinases Akt and extracellular signal–regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. Efficacious antitumor therapeutic agent Prime Source Information:

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产品规格

产品品牌

axonmedchem

产品概述

产品详情

TIC 10 active isomer - Angular TIC 10 | Active isomer 2

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2300

CAS [1616632-77-9]

MF C24H26N4O
MW 386.49

Purity: 99%
Soluble in DMSO

TIC 10 active isomer

Description

Potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner. TIC10/ONC201 inactivates kinases Akt and extracellular signal–regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. Efficacious antitumor therapeutic agent

Prime Source Information:
Axon 2300 is the confirmed 'angular' bio-active regio-isomer '2' as identified in the recently published issue of Angew. Chem. 2014, 126, 6746 –6749!