产品名称 S 12
产品货号 Axon 2165 CAS [258264-62-9] MF C17H12BrNO5MW 390.18 Purity: 99% Soluble in DMSO Description Survivin inhibitor. Alters spindle formation, causing mitotic arrest (by disrupting metaphase at the G2/M stage) and cell death. S 12 inhibits tumor growth in vitro and in vivo, and effectively inhibits cell proliferation and tumor growth independently of p53 status. References Certificates Categories Extra info A. Berezov et al. Disabling the mitotic spindle and tumor growth by targeting a cavity-induced allosteric site of survivin. Oncogene 2012, 31, 1938–1948. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Ubiquitin IAP Survivin inhibitor Chemical name 3-(2-(benzo[d][1,3]dioxol-5-yl)-2-oxoethyl)-5-bromo-3-hydroxyindolin-2-one Parent CAS No. [258264-62-9] Order Size Unit Price Stock 10 mg €105.00 In Stock
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S 12

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2165

CAS [258264-62-9]

MF C17H12BrNO5
MW 390.18

  • Purity: 99%
  • Soluble in DMSO

S 12

Description

Survivin inhibitor. Alters spindle formation, causing mitotic arrest (by disrupting metaphase at the G2/M stage) and cell death. S 12 inhibits tumor growth in vitro and in vivo, and effectively inhibits cell proliferation and tumor growth independently of p53 status.
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