产品名称

LCS-1

产品货号

Axon 2176 CAS [41931-13-9] MF C11H8Cl2N2OMW 255.10 Purity: 99% Soluble in DMSO Description Inhibitor of superoxide dismutase 1 (SOD1). Inhibits SOD1 enzymatic activity in vitro (IC50: 0.19 μM for cell growth inhibition in KRAS mutated H358 cell lines). Conversely, (over-) expression of SOD1 cDNA showed about a threefold reduction in sensitivity to LCS-1 and increased proliferation of H358 cells. Additionally, LCS-1 can prevent serum-induced activation of the ERK and PI 3-kinase/AKT signaling pathways. KEYWORDS: LCS-1 | supplier | SOD1 inhibitor | LCS1 | CAS [41931-13-9] | Superoxide | SOD1 | superoxide dismutase 1 | KRAS | ERK | PI3K | AKT | signaling | lung cancer

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

LCS-1

Based on 89 publications in PubMed 9 10 89

Axon 2176

CAS [41931-13-9]

MF C11H8Cl2N2O
MW 255.10

Purity: 99%
Soluble in DMSO

LCS-1

Description

Inhibitor of superoxide dismutase 1 (SOD1). Inhibits SOD1 enzymatic activity in vitro (IC50: 0.19 μM for cell growth inhibition in KRAS mutated H358 cell lines). Conversely, (over-) expression of SOD1 cDNA showed about a threefold reduction in sensitivity to LCS-1 and increased proliferation of H358 cells. Additionally, LCS-1 can prevent serum-induced activation of the ERK and PI 3-kinase/AKT signaling pathways.

KEYWORDS: LCS-1 | supplier | SOD1 inhibitor | LCS1 | CAS [41931-13-9] | Superoxide | SOD1 | superoxide dismutase 1 | KRAS | ERK | PI3K | AKT | signaling | lung cancer

R. Somwar et al. Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines. PNAS 2011, 108, 16375-16380.

Inhibits SOD1 enzymatic activity. Lead compound for lung cancer therapeutics

Chemical name

4,5-dichloro-2-m-tolylpyridazin-3(2H)-one

Parent CAS No.

[41931-13-9]

产品资料