产品名称

APS-2-79

产品货号

Axon 2611 CAS [2002381-31-7] MF C23H21N3O3.HClMW 423.89 Purity: 98% Soluble in DMSO Description Small molecule that stabilizes the KSR (Kinase suppressor of Ras) inactive state and antagonizes oncogenic Ras signalling (IC50 value 120 nM against ATP-biotin probe-labelling of KSR2). Furthermore, APS-2-79 modulates KSR-dependent MAPK signaling, and increases the potency of several MEK inhibitors, specifically within Ras-mutant cell lines by antagonizing release of negative feedback signaling. KEYWORDS: APS-2-79 | supplier | KSR/Raf inhibitor | APS2-79 | CAS [2002381-31-7] | [ 2002381-25-9] | MEK | KSR2 | Kinase suppressor of Ras | Raf | MAPK | K-Ras | mitogen activated | oncogenic

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

APS-2-79

Based on 4 reference(s) in Google Scholar 9 10 4

Axon 2611

CAS [2002381-31-7]

MF C23H21N3O3.HCl
MW 423.89

Purity: 98%
Soluble in DMSO

APS-2-79

Description

Small molecule that stabilizes the KSR (Kinase suppressor of Ras) inactive state and antagonizes oncogenic Ras signalling (IC50 value 120 nM against ATP-biotin probe-labelling of KSR2). Furthermore, APS-2-79 modulates KSR-dependent MAPK signaling, and increases the potency of several MEK inhibitors, specifically within Ras-mutant cell lines by antagonizing release of negative feedback signaling.

KEYWORDS: APS-2-79 | supplier | KSR/Raf inhibitor | APS2-79 | CAS [2002381-31-7] | [ 2002381-25-9] | MEK | KSR2 | Kinase suppressor of Ras | Raf | MAPK | K-Ras | mitogen activated | oncogenic

NS Dhawan et al. Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature. 2016 Aug 24;537(7618):112-116.

Inhibitor of KSR and oncogenic Ras signaling

Chemical name

6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine hydrochloride

Parent CAS No.

[ 2002381-25-9]

产品资料