| 产品名称 | GSK 269962A - GSK 269962 |
| 产品货号 | Axon 1167 CAS [850664-21-0] MF C29H30N8O5MW 570.60 Purity: 99% Soluble in DMSO Description Highly potent and selective inhibitor of Rho-Kinase (ROCK), with IC50 values: 1.6 nM toward ROCK1 and 6 nM toward ROCK2 and high kinase selectivity (>30 fold selective for ROCK compared to other protein kinases tested) and with antihypertensive activity; cardiovascular diseases category. GSK269962A has a much improved potency and selectivity in comparison with Y-27632, which has IC50 values of 140-220 nM for ROCK1 and ROCK2 References Certificates Categories Extra info C Doe et al. Novel Rho Kinase Inhibitors with Anti-inflammatory and Vasodilatory Activities. J. Pharmacol. Exp. Ther. 2007, 320, 89-98. D Schaafsma et al. Rho kinase inhibitors: A novel therapeutical intervention in asthma? Eur. J. Pharmacol. 2008, 585(2-3), 398-406. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Stem Cell ROCK TGF-β EC 2.7.11.1 ROCK1 and ROCK2 inhibitor Chemical name N-{3-[2-(4-Amino-furazan-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yloxy]-phenyl}-4-(2-morpholin-4-yl-ethoxy)-benzamide Parent CAS No. [850664-21-0] Order Size Unit Price Stock 2 mg €65.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
GSK 269962A - GSK 269962Axon 1167 CAS [850664-21-0] MF C29H30N8O5
Description
Highly potent and selective inhibitor of Rho-Kinase (ROCK), with IC50 values: 1.6 nM toward ROCK1 and 6 nM toward ROCK2 and high kinase selectivity (>30 fold selective for ROCK compared to other protein kinases tested) and with antihypertensive activity; cardiovascular diseases category. GSK269962A has a much improved potency and selectivity in comparison with Y-27632, which has IC50 values of 140-220 nM for ROCK1 and ROCK2
ROCK1 and ROCK2 inhibitor
Chemical nameN-{3-[2-(4-Amino-furazan-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yloxy]-phenyl}-4-(2-morpholin-4-yl-ethoxy)-benzamide Parent CAS No.[850664-21-0] |
| 产品资料 |
