| 产品名称 | PPQ 102 |
| 产品货号 | Axon 2295 CAS [931706-15-9] MF C26H22N4O3MW 438.48 Purity: 99% Soluble in DMSO Description Potent CFTR inhibitor (IC50 value ca 90 nM in CFTR chloride conductance essay). PPQ 102 acts by a mechanism involving stabilization of the channel closed-state. Prevented cyst expansion and reduced the size of preformed cysts in an embryonic kidney organ culture model of Polycystic kidney disease (PKD). References Certificates Categories Extra info L. Tradtrantip et al. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J. Med. Chem. 2009, 52, 6447-6455. D.S. Snyder et al. Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease. J. Med. Chem. 2011, 54, 5468-5477. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CFTR EC 3.6.3.49 CFTR inhibitor that acts by a mechanism involving stabilization of the channel closed-state Chemical name 6,7-dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenyl-pyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione Parent CAS No. [931706-15-9] Order Size Unit Price Stock 5 mg €100.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
PPQ 102Axon 2295 CAS [931706-15-9] MF C26H22N4O3
Description
Potent CFTR inhibitor (IC50 value ca 90 nM in CFTR chloride conductance essay). PPQ 102 acts by a mechanism involving stabilization of the channel closed-state. Prevented cyst expansion and reduced the size of preformed cysts in an embryonic kidney organ culture model of Polycystic kidney disease (PKD).
CFTR inhibitor that acts by a mechanism involving stabilization of the channel closed-state
Chemical name6,7-dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenyl-pyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione Parent CAS No.[931706-15-9] |
| 产品资料 |
