| 产品名称 | TY 52156 |
| 产品货号 | Axon 2404 CAS [934369-14-9] MF C18H19Cl2N3OMW 364.27 Purity: 99% Soluble in DMSO Description Selective, competitive, and orally active S1P3 antagonist that restores S1P reduced coronary blood flow, and inhibits Rho dependent activation and calcium signaling. TY52156 inhibited FTY720-induced S1P3 receptor-mediated bradycardia in vivo. References Certificates Categories Extra info A. Murakami et al. Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist. Mol Pharmacol. 2010 Apr;77(4):704-13. N.J. Pyne et al. Selectivity and specificity of sphingosine 1-phosphate receptor ligands: "off-targets" or complex pharmacology? Front Pharmacol. 2011 May 31;2:26. K. Sobel et al. Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling. J Biol Chem. 2013 May 24;288(21):14839-51. Certificate of Analysis Material Safety Data Sheet Angiogenesis Apoptosis Cardiovascular Immunology Miscellaneous A13 S1PR3 Selective, competitive, and orally active S1P3 antagonist Chemical name N,N'-bis(4-chlorophenyl)-3,3-dimethyl-2-oxobutanehydrazonamide Parent CAS No. [934369-14-9] Order Size Unit Price Stock 10 mg €125.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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| 产品详情 |
TY 52156Axon 2404 CAS [934369-14-9] MF C18H19Cl2N3O
Description
Selective, competitive, and orally active S1P3 antagonist that restores S1P reduced coronary blood flow, and inhibits Rho dependent activation and calcium signaling. TY52156 inhibited FTY720-induced S1P3 receptor-mediated bradycardia in vivo.
Selective, competitive, and orally active S1P3 antagonist
Chemical nameN,N'-bis(4-chlorophenyl)-3,3-dimethyl-2-oxobutanehydrazonamide Parent CAS No.[934369-14-9] |
| 产品资料 |
