| 产品名称 | K 145 hydrochloride |
| 产品货号 | Axon 2235 CAS [1449240-68-9] MF C18H24N2O3S.HClMW 384.92 Purity: 99% Soluble in water and DMSO Description Selective, substrate competitive Sphingosine Kinase-2 inhibitor (SphK2; IC50 value 4.30 µM) and anticancer agent. K145 suppressed the S1P level, and significantly inhibited the growth of U937 tumors in nude mice by both intraperitoneal and oral administration.K145 significantly inhibited the phosphorylation of FTY720, ERK and Akt upon treatment of U937 cells, but does not interfere with CERK and/or ceramide synthase. References Certificates Categories Extra info K. Liu et al. Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent. PLoS One. 2013, 8, e56471. Certificate of Analysis Material Safety Data Sheet Angiogenesis Apoptosis Cell Signaling & Oncology Immunology Miscellaneous EC 2.7.1.91 SphK Selective, substrate competitive SphK2 inhibitor Chemical name 3-(2-aminoethyl)-5-(3-(4-butoxyphenyl)propylidene)thiazolidine-2,4-dione hydrochloride Parent CAS No. [1309444-75-4] Order Size Unit Price Stock 10 mg €105.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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K 145 hydrochlorideAxon 2235 CAS [1449240-68-9] MF C18H24N2O3S.HCl
Description
Selective, substrate competitive Sphingosine Kinase-2 inhibitor (SphK2; IC50 value 4.30 µM) and anticancer agent. K145 suppressed the S1P level, and significantly inhibited the growth of U937 tumors in nude mice by both intraperitoneal and oral administration.K145 significantly inhibited the phosphorylation of FTY720, ERK and Akt upon treatment of U937 cells, but does not interfere with CERK and/or ceramide synthase.
Selective, substrate competitive SphK2 inhibitor
Chemical name3-(2-aminoethyl)-5-(3-(4-butoxyphenyl)propylidene)thiazolidine-2,4-dione hydrochloride Parent CAS No.[1309444-75-4] |
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