产品名称 SKI II - SKI 2
产品货号 Axon 2782 CAS [312636-16-1] MF C15H11ClN2OSMW 302.78 Purity: 99% Soluble in DMSO Description SKI II is an orally bioavailable sphingosine kinase (SK or SphK) inhibitor (IC50 value of 0.5 µM) without competition at the ATP-binding site of SK. Moreover, SKI II showed no inhibition on a small panel of human protein kinases (ERK2 and PKC-α) and a lipid kinase (PI3K). SKI II inhibited cancer cell proliferation, induced apoptosis and inhibited tumor growth in mice. KEYWORDS: SKI II | supplier | SphK inhibitor | SKI 2 | SKIII | SKI-II | SKI2 | SKI-2 | CAS [312636-16-1] | Sphingosine | SphK1 | SphK2 | Inhibitor | Enzymes | Apoptosis
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SKI II - SKI 2

Based on 44 reference(s) in Google Scholar 8 10 44

Axon 2782

CAS [312636-16-1]

MF C15H11ClN2OS
MW 302.78

  • Purity: 99%
  • Soluble in DMSO

SKI II

Description

SKI II is an orally bioavailable sphingosine kinase (SK or SphK) inhibitor (IC50 value of 0.5 µM) without competition at the ATP-binding site of SK. Moreover, SKI II showed no inhibition on a small panel of human protein kinases (ERK2 and PKC-α) and a lipid kinase (PI3K). SKI II inhibited cancer cell proliferation, induced apoptosis and inhibited tumor growth in mice.

KEYWORDS: SKI II | supplier | SphK inhibitor | SKI 2 | SKIII | SKI-II | SKI2 | SKI-2 | CAS [312636-16-1] | Sphingosine | SphK1 | SphK2 | Inhibitor | Enzymes | Apoptosis

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