产品名称

K6PC-5

产品货号

Axon 2484 CAS [756875-51-1] MF C19H37NO4MW 343.50 Purity: 98% Soluble in DMSO Description Sphingosine kinase 1 (SphK1 or SK1) activator that increases sphingosine-1-phosphate (S1P) production, induces Akt phosphorylation in cultured osteoblasts, and protects them from Dex-induced apoptosis and necrosis. K6PC-5 acts to regulate both differentiation and proliferation of keratinocytes via [Ca2+]i responses through S1P production, which may represent a novel approach for treatment of skin disorders characterized by abnormal differentiation and proliferation, such as atopic dermatitis and psoriasis. Furthermore, a useful tool in animal or clinical studies for its antiglucocorticoids-associated osteonecrosis potential. KEYWORDS: K6PC-5 | supplier | SphK1 activator | K6PC5 | CAS [756875-51-1] | Sphingosine | SphK | Activator | sphingosine-1-phosphate | S1P | apoptosis | necrosis | epidermal | differentiation | proliferation | keratinocytes | calcium signaling | dermatitis | psoriasis

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

K6PC-5

Based on 83 reference(s) in Google Scholar 9 10 83

Axon 2484

CAS [756875-51-1]

MF C19H37NO4
MW 343.50

Purity: 98%
Soluble in DMSO

K6PC-5

Description

Sphingosine kinase 1 (SphK1 or SK1) activator that increases sphingosine-1-phosphate (S1P) production, induces Akt phosphorylation in cultured osteoblasts, and protects them from Dex-induced apoptosis and necrosis. K6PC-5 acts to regulate both differentiation and proliferation of keratinocytes via [Ca²⁺]_i responses through S1P production, which may represent a novel approach for treatment of skin disorders characterized by abnormal differentiation and proliferation, such as atopic dermatitis and psoriasis. Furthermore, a useful tool in animal or clinical studies for its antiglucocorticoids-associated osteonecrosis potential.