产品名称

Sulfasalazine - SSZ

产品货号

Axon 2070 CAS [599-79-1] MF C18H14N4O5SMW 398.39 Purity: 99% Soluble in 0.1N NaOH(aq) and DMSO Description An old drug with new applications. A Sulfa drug developed in 1950s and used in the treatment of inflammatory bowel disease and rheumatoid arthritis. This old drug was found in recent study to reverse severe liver disease. Sulfasalazine (SSZ) is a potent and selective inhibitor of NF-κB activation via its ability to block the activity of the inhibitor of κB (IκB) kinases α and β (IKKα and IKKβ). Sulfasalazine stimulates apoptosis of activated hepatic stellate cells and recovery from CCl4-induced fibrosis References Certificates Categories Extra info F Oakley et al. Inhibition of inhibitor of κB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis. Gastroenterology 2005, 128(1), 108–120. C Wahl et al. Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. J. Clin. Invest. 1998, 101(5), 1163. CK Weber et al. Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta. Gastroenterology. 2000, 119(5), 1209-1218. S Liptay et al. Molecular mechanisms of sulfasalazine-induced T-cell apoptosis. Br. J. Pharmacol. 2002, 137(5), 608-620. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Immunology Pain & Inflammation Transcription Factors NF-κB EC 2.7.11.10 IKK Pfizer Licensed Products IKK inhibitor Chemical name 2-hydroxy-5-((4-(N-pyridin-2-ylsulfamoyl)phenyl)diazenyl)benzoic acid Source information Pfizer compound; Sold for research purposes under agreement from Pfizer Inc. Parent CAS No. [599-79-1] Order Size Unit Price Stock 25 mg €45.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Sulfasalazine - SSZ

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2070

CAS [599-79-1]

MF C18H14N4O5S
MW 398.39

Purity: 99%
Soluble in 0.1N NaOH(aq) and DMSO

Sulfasalazine

Description

An old drug with new applications. A Sulfa drug developed in 1950s and used in the treatment of inflammatory bowel disease and rheumatoid arthritis. This old drug was found in recent study to reverse severe liver disease. Sulfasalazine (SSZ) is a potent and selective inhibitor of NF-κB activation via its ability to block the activity of the inhibitor of κB (IκB) kinases α and β (IKKα and IKKβ). Sulfasalazine stimulates apoptosis of activated hepatic stellate cells and recovery from CCl4-induced fibrosis