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产品名称 NS 19504
产品货号 Axon 2329 CAS [327062-46-4] MF C10H9BrN2SMW 269.16 Purity: 99% Soluble in DMSO Description Potent activator of large-conductance Ca2+-activated potassium channels (BK, KCa1.1, MaxiK; EC50 value 11 µM in a Tl+ assay) with a favorable selectivity profile in a screen of 68 receptors and by functional tests on Nav, Cav, SK, and IK channels. NS19504 potently inhibits urinary bladder spontaneous phasic contractions (SPCs) while having only a modest effect on contractions evoked by electrical field stimulation (EFS) and no effect on high K+-induced contractions. At a concentration of 10 µM, NS19504 was also found to inhbit the σ1 receptor, two transporters of neurotransmiters (DA and Norepinephrine), and soluble epoxide hydrolase (sEH). References Certificates Categories Extra info B. Nausch et al. NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions. J Pharmacol Exp Ther. 2014 Sep;350(3):520-30.   Y. Amano et al. Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg Med Chem. 2014 Apr 15;22(8):2427-34. Certificate of Analysis Material Safety Data Sheet Cardiovascular CNS KCa1.1 DRI NRI KCNMA1 Potent activator of large-conductance Ca2+-activated potassium (BK) channels Chemical name 5-(4-bromobenzyl)thiazol-2-amine Parent CAS No. [327062-46-4] Order Size Unit Price Stock 10 mg €90.00 In Stock
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NS 19504

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2329

CAS [327062-46-4]

MF C10H9BrN2S
MW 269.16

  • Purity: 99%
  • Soluble in DMSO

NS 19504

Description

Potent activator of large-conductance Ca2+-activated potassium channels (BK, KCa1.1, MaxiK; EC50 value 11 µM in a Tl+ assay) with a favorable selectivity profile in a screen of 68 receptors and by functional tests on Nav, Cav, SK, and IK channels. NS19504 potently inhibits urinary bladder spontaneous phasic contractions (SPCs) while having only a modest effect on contractions evoked by electrical field stimulation (EFS) and no effect on high K+-induced contractions. At a concentration of 10 µM, NS19504 was also found to inhbit the σ1 receptor, two transporters of neurotransmiters (DA and Norepinephrine), and soluble epoxide hydrolase (sEH).
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