产品名称

NS 1619

产品货号

Axon 2854 CAS [153587-01-0] MF C15H8F6N2O2MW 362.23 Purity: 98% Soluble in DMSO Description NS 1619 is a selective large-conductance Ca2+-activated K+ channel (BK channel) activator which decreased the mitochondrial membrane potential with an EC50 value of 3.6 μM. Besides induction of apoptosis, NS 1619 inhibits both mitochondrial function in the glioma cell line LN229, as well as proliferation of A2780 cells (IC50 value of 31.1 μM). These anticancer activities are associated with increased expression of p53, p21, and Bax. KEYWORDS: NS 1619 | supplier | BK channel activator | NS1619 | NS-1619 | CAS [153587-01-0] | Potassium | KCa1.1 | Opener | Ion Channels | Apoptosis | Glioma | A2780 | p53 | p21 | Bax

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

NS 1619

Based on 3 reference(s) in Google Scholar 8 10 3

Axon 2854

CAS [153587-01-0]

MF C15H8F6N2O2
MW 362.23

Purity: 98%
Soluble in DMSO

NS 1619

Description

NS 1619 is a selective large-conductance Ca2+-activated K+ channel (BK channel) activator which decreased the mitochondrial membrane potential with an EC50 value of 3.6 μM. Besides induction of apoptosis, NS 1619 inhibits both mitochondrial function in the glioma cell line LN229, as well as proliferation of A2780 cells (IC50 value of 31.1 μM). These anticancer activities are associated with increased expression of p53, p21, and Bax.

KEYWORDS: NS 1619 | supplier | BK channel activator | NS1619 | NS-1619 | CAS [153587-01-0] | Potassium | KCa1.1 | Opener | Ion Channels | Apoptosis | Glioma | A2780 | p53 | p21 | Bax