产品名称

TAK 259

产品货号

Axon 2579 CAS [1192347-42-4] MF C14H13Cl2N3O3S.HClMW 410.70 Purity: 99% Soluble in water and DMSO Description Novel, selective, and orally active α1D adrenoceptor antagonist (Ki value 1.1 nM, and 200-800 fold selective over α1A and α1B, respectively) with anti-urinary frequency effects: reducing human Ether-a-go-go-Related Gene (hERG) liabilities. Clinical candidate, and a promising novel therapeutic agent for the treatment of OAB (overactive bladder) symptoms. KEYWORDS: TAK 259 | supplier | α1D antagonist | TAK259 | CAS [1192347-42-4] | [1192348-73-4] | Adrenaline | Adrenoceptor α1 | GPCR | anti-urinary | hERG liabilities | human Ether-a-go-go-Related Gene | overactive bladder | OAB

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

TAK 259

Based on 5 reference(s) in Google Scholar 9 10 5

Axon 2579

CAS [1192347-42-4]

MF C14H13Cl2N3O3S.HCl
MW 410.70

Purity: 99%
Soluble in water and DMSO

TAK 259

Description

Novel, selective, and orally active α1D adrenoceptor antagonist (Ki value 1.1 nM, and 200-800 fold selective over α1A and α1B, respectively) with anti-urinary frequency effects: reducing human Ether-a-go-go-Related Gene (hERG) liabilities. Clinical candidate, and a promising novel therapeutic agent for the treatment of OAB (overactive bladder) symptoms.

N Sakauchi et al. Discovery of TAK-259 as a Novel, Selective, and Orally Active α1D Adrenoceptor Antagonist with Antiurinary Frequency Effects: Reducing Human Ether-a-go-go-Related Gene (hERG) Liabilities. J Med Chem. 2016 Apr 14;59(7):2989-3002.

Selective and orally active α1D adrenoceptor antagonist

Chemical name

5-chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrochloride

Parent CAS No.

[1192348-73-4]

产品资料