产品名称

AVE 0118 hydrochloride

产品货号

Axon 2243 CAS [498577-53-0 (parent)] MF C30H29N3O3.HClMW 516.03 Purity: 99% Soluble in water and DMSO Description Potassium channel blocker. AVE0118 caused concentration-dependent inhibition of Kv1.5 (IKur), Kv4.3 (Ito), Kir3.4 (IKAch), and IKr currents (IC50 values 6.2 μM, 3.4 μM, 4.5 μM, and 10 μM resp.). A potent and atrium selective antiarrhythmic compound with no apparent effect on ventricular repolarization. Noteworthy, the atrial selective and dose-dependent prolongation of atrial refractoriness (ERP) by AVE 0118 has been claimed to be an inhibitory effect of sodium channel activity in an atrial-selective manner, and may therefor contribute to anti-AF properties of AVE0118. References Certificates Categories Extra info H. Gögelein et al. Effects of the atrial antiarrhythmic drug AVE0118 on cardiac ion channels. Naun. Schmiedebergs Arch. Pharmacol. 2004, 370, 183-192. K.J. Wirth et al. Atrial effects of the novel K+-channel-blocker AVE0118 in anesthetized pigs. Cardiovascular Res. 2003, 60, 298-306. A. Burashnikov et al. Atrial-selective prolongation of refractory period with AVE0118 is due principally to inhibition of sodium channel activity. J. Cardiovasc. Pharmacol. 2012, 59, 539-546. Certificate of Analysis Material Safety Data Sheet Cardiovascular Cell Signaling & Oncology CNS Diabetes & Metabolism Pain & Inflammation Kv1.5 Kv4.3 Kir4.3 KCND3 KCNJ5 KCNE1 Potassium channel blocker (Kv1.5 (IKur), Kv4.3 (Ito), Kir3.4 (IKAch), and IKr currents) Chemical name 2'-((2-(4-methoxyphenyl)acetamido)methyl)-N-(2-(pyridin-3-yl)ethyl)biphenyl-2-carboxamide hydrochloride Parent CAS No. [498577-53-0] Order Size Unit Price Stock 5 mg €120.00 In Stock

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axonmedchem

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AVE 0118 hydrochloride

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2243

CAS [498577-53-0 (parent)]

MF C30H29N3O3.HCl
MW 516.03

Purity: 99%
Soluble in water and DMSO

AVE 0118 hydrochloride

Description

Potassium channel blocker. AVE0118 caused concentration-dependent inhibition of Kv1.5 (IKur), Kv4.3 (Ito), Kir3.4 (IKAch), and IKr currents (IC50 values 6.2 μM, 3.4 μM, 4.5 μM, and 10 μM resp.). A potent and atrium selective antiarrhythmic compound with no apparent effect on ventricular repolarization. Noteworthy, the atrial selective and dose-dependent prolongation of atrial refractoriness (ERP) by AVE 0118 has been claimed to be an inhibitory effect of sodium channel activity in an atrial-selective manner, and may therefor contribute to anti-AF properties of AVE0118.