产品名称

SCH 79797 dihydrochloride

产品货号

Axon 1275 CAS [1216720-69-2] MF C23H25N5.2HClMW 444.40 Purity: 99% Soluble in DMSO and Ethanol Description Potent and selective non-peptide PAR1 antagonist. KEYWORDS: SCH 79797 dihydrochloride | supplier | PAR1 antagonist | SCH79797 HCl | CAS [1216720-69-2] | [245520-69-8] | Thrombin | PAR | myocardial | ischemia | reperfusion | GPCR | protease-activated receptor 1 | apoptosis | airway | inflammation | fibrosis

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

SCH 79797 dihydrochloride

Based on 133 publications in PubMed 8 10 133

Axon 1275

CAS [1216720-69-2]

MF C23H25N5.2HCl
MW 444.40

Purity: 99%
Soluble in DMSO and Ethanol

SCH 79797 dihydrochloride

Description

Potent and selective non-peptide PAR1 antagonist.

KEYWORDS: SCH 79797 dihydrochloride | supplier | PAR1 antagonist | SCH79797 HCl | CAS [1216720-69-2] | [245520-69-8] | Thrombin | PAR | myocardial | ischemia | reperfusion | GPCR | protease-activated receptor 1 | apoptosis | airway | inflammation | fibrosis

JI Strande et al. SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts. Bas. Res. Cardiol. 2007, 102(4), 350.

C di Serio et al. Protease-activated receptor 1-selective antagonist SCH79797 inhibits cell proliferation and induces apoptosis by a protease-activated receptor 1-independent mechanism. Bas. Clin. Pharmacol. Toxicol. 2007, 101(1), 63-69.

E Sokolova and G Reiser. A novel therapeutic target in various lung diseases: Airway proteases and protease-activated receptors. Pharmacol. Ther. 2007, 115(1), 70-83.

P Zania et al. Blockade of angiogenesis by small molecule antagonists to protease-activated receptor-1: association with endothelial cell growth suppression and induction of apoptosis. J. Pharm. Exp. Ther. 2006, 318(1), 246.

HS Ahn et al. Inhibition of cellular action of thrombin by N3-cyclopropyl-7-{[4-(1-methylethyl)phenyl]methyl}-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist. Biochem. Pharmacol. 2000, 60(10), 1425-1434.

List of publications using SCH 79797 dihydrochloride (Axon 1275) purchased from Axon Medchem

Cell Signaling & Oncology A15 Thrombin (PAR)

PAR1 antagonist

Chemical name

N*3*-Cyclopropyl-7-(4-isopropyl-benzyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride

Parent CAS No.

[245520-69-8]

产品资料