SCH 530348 - Vorapaxar | MK 5348

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 1755

CAS [618385-01-6]

MF C29H33FN2O4
MW 492.58

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

SCH 530348

Description

Potent and orally active thrombin receptor (or protease-activated receptor 1, PAR-1) antagonist (Ki value 8.1 nM) that inhibits thrombin-induced platelet activation.

S Chackalamannil et al. Discovery of a Novel, Orally Active Himbacine-Based Thrombin Receptor Antagonist (SCH 530348) with Potent Antiplatelet Activity. J. Med. Chem. 2008, 51(11), 3061–3064.

J Oestreich. SCH-530348, a thrombin receptor (PAR-1) antagonist for the prevention and treatment of atherothrombosis. Curr. Opin. Investig. Drugs. 2009, 10(9), 988-996.

L Aerts et al. Modulation of Protease Activated Receptor 1 Influences Human Metapneumovirus Disease Severity in a Mouse Model. PLoS One. 2013; 8(8): e72529.

List of publications utilizing Vorapaxar - SCH530348 (Axon 1755) purchased from Axon Medchem

Cell Signaling & Oncology A15 Thrombin (PAR)

PAR1 antagonist

Chemical name

ethyl (1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-ylcarbamate

Parent CAS No.

[618385-01-6]

产品资料