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产品名称 CP 945598 - Otenabant
产品货号 Axon 2015 CAS [686344-29-6] MF #N/AMW 510.42 Purity: 98% Soluble in 0.1N HCl(aq) and DMSO Description Potent and selective cannabinoid CB1 receptor antagonist (Ki values 0.7 nM and 0.2 nM in binding and functional assays, respectively) for the management of obesity. CP945598 exhibits a >10000 fold selectivity over CB2, and lacks significant, or meaningful, activity at a large panel of receptors, enzymes, and ion channels. Available as HCl salt as well (Axon 2119) References Certificates Categories Extra info J.R. Hadcock et al. In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB(1) receptor antagonist for the management of obesity. Biochem Biophys Res Commun. 2010 Apr 2;394(2):366-71.   L.J. Aronne et al. Efficacy and safety of CP-945,598, a selective cannabinoid CB1 receptor antagonist, on weight loss and maintenance. Obesity (Silver Spring). 2011 Jul;19(7):1404-14. Certificate of Analysis Material Safety Data Sheet Cardiovascular CNS Diabetes & Metabolism Pain & Inflammation CB1 A13 Pfizer Licensed Products CB1 antagonist Chemical name 1-(8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl)-4-(ethylamino)piperidine-4-carboxamide Source information Pfizer compound; Sold for research purposes under agreement from Pfizer Inc. Parent CAS No. [686344-29-6] Order Size Unit Price Stock 10 mg €135.00 In Stock
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CP 945598 - Otenabant

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2015

CAS [686344-29-6]

MF #N/A
MW 510.42

  • Purity: 98%
  • Soluble in 0.1N HCl(aq) and DMSO

CP 945598

Description

Potent and selective cannabinoid CB1 receptor antagonist (Ki values 0.7 nM and 0.2 nM in binding and functional assays, respectively) for the management of obesity. CP945598 exhibits a >10000 fold selectivity over CB2, and lacks significant, or meaningful, activity at a large panel of receptors, enzymes, and ion channels. Available as HCl salt as well (Axon 2119)
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