产品名称 Chloroquine diphosphate - NSC 14050
产品货号 Axon 2431 CAS [50-63-5] MF C18H26ClN3.2H3PO4MW 515.86 Purity: 99% Optical purity: Racemate Soluble in water Description Classical antimalarial drug (CQ) with lysosomotropic effects causing necrosis and apoptosis. Inhibitor of hemozoin (β-​hematin) formation in malaria (Plasmodium strains) affected red blood cells. Nowadays, most of the Plasmodium falciparum strains are resistant to this drug. Chloroquine was found to inhibit the human thiamine transporter ThTr-2 (SLC19A3), and to inhibit cell growth and to induce cell death in A549 lung cancer cells. KEYWORDS: Chloroquine diphosphate | supplier | Antimalarial drug | NSC 14050 | NSC14050 | CQ | CAS [50-63-5] | [54-05-7] | beta-hematin | Plasmodium | hemoglobin | hemozoin | thiamine | transporter | ThTr-2 | SLC19A3 | apoptosis | necrosis
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Chloroquine diphosphate - NSC 14050

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Axon 2431

CAS [50-63-5]

MF C18H26ClN3.2H3PO4
MW 515.86

  • Purity: 99%
  • Optical purity: Racemate
  • Soluble in water

Chloroquine diphosphate

Description

Classical antimalarial drug (CQ) with lysosomotropic effects causing necrosis and apoptosis. Inhibitor of hemozoin (β-​hematin) formation in malaria (Plasmodium strains) affected red blood cells. Nowadays, most of the Plasmodium falciparum strains are resistant to this drug. Chloroquine was found to inhibit the human thiamine transporter ThTr-2 (SLC19A3), and to inhibit cell growth and to induce cell death in A549 lung cancer cells.

KEYWORDS: Chloroquine diphosphate | supplier | Antimalarial drug | NSC 14050 | NSC14050 | CQ | CAS [50-63-5] | [54-05-7] | beta-hematin | Plasmodium | hemoglobin | hemozoin | thiamine | transporter | ThTr-2 | SLC19A3 | apoptosis | necrosis

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