产品名称

CP 690550 - Tasocitinib | Tofacitinib

产品货号

Axon 1338 CAS [477600-75-2] MF C16H20N6OMW 312.37 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Janus Kinase 3 (JAK3) inhibitor; an immunosuppressive agent exhibiting potent effects in preclinical transplantation and arthritis models; clinically safe and effective in preventing transplant rejection and improving symptoms of rheumatoid arthritis and psoriasis.This product is also available as its citrate salt form, Tofacitinib citrate (Axon 2072). KEYWORDS: CP 690550 | supplier | JAK3 inhibitor | Tasocitinib | Tofacitinib | CP690550 | CP-690550 | CAS [477600-75-2] | JAK-STAT Pathway | JAK | Janus Kinase | immunosuppressive | transplantation | rheumatoid | arthritis | rejection | psoriasis

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

CP 690550 - Tasocitinib | Tofacitinib

Based on 772 publications in PubMed 10 10 772

Axon 1338

CAS [477600-75-2]

MF C16H20N6O
MW 312.37

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

CP 690550

Description

Janus Kinase 3 (JAK3) inhibitor; an immunosuppressive agent exhibiting potent effects in preclinical transplantation and arthritis models; clinically safe and effective in preventing transplant rejection and improving symptoms of rheumatoid arthritis and psoriasis.
This product is also available as its citrate salt form, Tofacitinib citrate (Axon 2072).

KEYWORDS: CP 690550 | supplier | JAK3 inhibitor | Tasocitinib | Tofacitinib | CP690550 | CP-690550 | CAS [477600-75-2] | JAK-STAT Pathway | JAK | Janus Kinase | immunosuppressive | transplantation | rheumatoid | arthritis | rejection | psoriasis

LA Sorbera et al. CP-690550, Drugs Fut. 2007, 32(8), 674.

AC Papageorgiou and LEK Wikman, Is JAK3 a new drug target for immunomodulation-based therapies? Trends Pharmacol. Sci. 2004, 25(11), 558-562.

E Kudlacz et al. The novel JAK-3 inhibitor CP-690550 is a potent immunosuppressive agent in various murine models. Am. J. Transplant. 2004, 4(1), 51-7.

E Kudlacz et al. The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia. Eur. J. Pharmacol. 2008, 582(1-3), 154-61.

PS Changelian et al. Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor. Sci. 2003, 302(5646), 875-878.

List of publications using CP 690550 (Axon 1338) purchased from Axon Medchem

Cell Signaling & Oncology Epigenetics Immunology Immunomodulator JAK-STAT EC 2.7.10.2 JAK Pfizer Licensed Products

JAK3 inhibitor

Chemical name

3-{(3R,4R)-4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-3-oxo-propionitrile

Source information

Pfizer compound; Sold for research purposes under agreement from Pfizer Inc.

Parent CAS No.

[477600-75-2]

产品资料