产品名称

CNV 1014802 hydrochloride - GSK 1014802 HCl | GSK2 HCl | Raxatrigine HCl | BIIB 074 HCl | Vixotrigine HCl

产品货号

Axon 2548 CAS [934240-31-0] MF C18H19FN2O2.HClMW 350.82 Purity: 99% Soluble in water and DMSO Description Sodium channel blocker with potent anticonvulsant activity; potential for novel treatment for Schizophrenia. CNV 1014802 (GSK2) was tested in clinical trials for treatment of trigeminal neuralgia, and shows selectivity for the Nav1.7 subtype over the other subtypes tested (Nav1.1, Nav1.2, Nav1.3, Nav1.5, Nav1.6 and TTX-R), for both the resting and depolarized states. The parent molecule of CNV 1014802 (Axon 1899) is available as well. KEYWORDS: CNV 1014802 hydrochloride | supplier | Na+ channel blocker | GSK 1014802 HCl | GSK2 HCl | Raxatrigine HCl | BIIB 074 HCl | Vixotrigine HCl | CNV1014802 hydrochloride | CNV-1014802 hydrochloride | GSK1014802 HCl | GSK-1014802 HCl | GSK 2 HCl | GSK-2 HCl | BIIB074 HCl | BIIB-074 HCl | CAS [934240-31-0] | [934240-30-9] | Sodium | Nav1.7 | Nav1.2 | Nav1.6 | Nav1.3 | Blocker | Ion Channels | anticonvulsant | Schizophrenia | trigeminal neuralgia | neuropathic | pain

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

CNV 1014802 hydrochloride - GSK 1014802 HCl | GSK2 HCl | Raxatrigine HCl | BIIB 074 HCl | Vixotrigine HCl

Based on 56 reference(s) in Google Scholar 9 10 56

Axon 2548

CAS [934240-31-0]

MF C18H19FN2O2.HCl
MW 350.82

Purity: 99%
Soluble in water and DMSO

CNV 1014802 hydrochloride

Description

Sodium channel blocker with potent anticonvulsant activity; potential for novel treatment for Schizophrenia. CNV 1014802 (GSK2) was tested in clinical trials for treatment of trigeminal neuralgia, and shows selectivity for the Nav1.7 subtype over the other subtypes tested (Nav1.1, Nav1.2, Nav1.3, Nav1.5, Nav1.6 and TTX-R), for both the resting and depolarized states.

The parent molecule of CNV 1014802 (Axon 1899) is available as well.

KEYWORDS: CNV 1014802 hydrochloride | supplier | Na+ channel blocker | GSK 1014802 HCl | GSK2 HCl | Raxatrigine HCl | BIIB 074 HCl | Vixotrigine HCl | CNV1014802 hydrochloride | CNV-1014802 hydrochloride | GSK1014802 HCl | GSK-1014802 HCl | GSK 2 HCl | GSK-2 HCl | BIIB074 HCl | BIIB-074 HCl | CAS [934240-31-0] | [934240-30-9] | Sodium | Nav1.7 | Nav1.2 | Nav1.6 | Nav1.3 | Blocker | Ion Channels | anticonvulsant | Schizophrenia | trigeminal neuralgia | neuropathic | pain

CH Large et al. The efficacy of sodium channel blockers to prevent phencyclidine-induced cognitive dysfunction in the rat: potential for novel treatments for schizophrenia. J. Pharmacol. Exp. Ther. 2011, 338(1), 100-113.

J.M. Zakrzewska et al. Novel design for a phase IIa placebo-controlled, double-blind randomized withdrawal study to evaluate the safety and efficacy of CNV1014802 in patients ith trigeminal neuralgia. Trials. 2013 Nov 23;14:402.

A. Nardi et al. Advances in targeting voltage-gated sodium channels with small molecules. ChemMedChem. 2012 Oct;7(10):1712-40.

C.H. Large et al. The relationship between sodium channel inhibition and anticonvulsant activity in a model of generalised seizure in the rat. Epilepsy Res. 2009 Jul;85(1):96-106.

JR Deuis et al. Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain. Toxins (Basel). 2016 Mar 17;8(3). pii: E78.

CNS Pain & Inflammation Nav1.7 Unclassified Nav1.2 Nav1.6 Nav1.3

Na+ channel blocker; anti-convulsant

Chemical name

(2S,5R)-5-(4-(2-fluorobenzyloxy)phenyl)pyrrolidine-2-carboxamide hydrochloride

Parent CAS No.

[934240-30-9]

产品资料