产品名称

MLN 9708 - Ixazomib citrate

产品货号

Axon 2557 CAS [1201902-80-8] MF C20H23BCl2N2O9MW 517.12 Purity: 99% Soluble in DMSO Description Citrate prodrug of MLN 2238 (Ixazomib; Axon 2556), a selective and reversible inhibitor of the β5 subunit sites of the 20S proteasome with antitumor activity in various malignancies. MLN 9708 exhibits improved pharmacodynamics and antitumor activity compared with bortezomib in various B-cell lymphoma models, due to a greater tumor to blood ratio of proteasome inhibition that ultimately translates into improved tumor pharmacodynamic response and antitumor activity in several tumor xenograft models. Approved by the FDA in November 2015 for multiple myeloma treatment. KEYWORDS: MLN 9708 | supplier | Proteasome inhibitor | Ixazomib citrate | MLN9708 | CAS [1201902-80-8] | Ubiquitin | Proteasome 20S | Inhibitor | MLN2238 | MLN 2238 | prodrug | β5 subunit | B-cell lymphoma | FDA approved

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

MLN 9708 - Ixazomib citrate

Based on 273 reference(s) in Google Scholar 10 10 273

Axon 2557

CAS [1201902-80-8]

MF C20H23BCl2N2O9
MW 517.12

Purity: 99%
Soluble in DMSO

MLN 9708

Description

Citrate prodrug of MLN 2238 (Ixazomib; Axon 2556), a selective and reversible inhibitor of the β5 subunit sites of the 20S proteasome with antitumor activity in various malignancies. MLN 9708 exhibits improved pharmacodynamics and antitumor activity compared with bortezomib in various B-cell lymphoma models, due to a greater tumor to blood ratio of proteasome inhibition that ultimately translates into improved tumor pharmacodynamic response and antitumor activity in several tumor xenograft models. Approved by the FDA in November 2015 for multiple myeloma treatment.