产品名称

Salermide

产品货号

Axon 2704 CAS [1105698-15-4] MF C26H22N2O2MW 394.47 Purity: 99% Soluble in DMSO Description Salermide is a reverse amide with a potent in vitro inhibitory effect on Sirt1 and Sirt2. Salermide was well tolerated by mice at concentrations up to 100 μM and prompted tumour-specific cell death in a wide range of human cancer cell lines. It induces massive apoptosis in cancer but not in non-transformed cultured cells. The apoptotic effect of Salermide is in part because of the reactivation of proapoptotic genes that are epigenetically repressed by Sirt1 exclusively in cancer cells. KEYWORDS: Salermide | supplier | SIRT inhibitor | CAS [1105698-15-4] | Histone | SIRT | Inhibitor | Enzymes

产品价格

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产品规格

产品品牌

axonmedchem

产品概述

产品详情

Salermide

Based on 30 reference(s) in Google Scholar 9 10 30

Axon 2704

CAS [1105698-15-4]

MF C26H22N2O2
MW 394.47

Purity: 99%
Soluble in DMSO

Salermide

Description

Salermide is a reverse amide with a potent in vitro inhibitory effect on Sirt1 and Sirt2. Salermide was well tolerated by mice at concentrations up to 100 μM and prompted tumour-specific cell death in a wide range of human cancer cell lines. It induces massive apoptosis in cancer but not in non-transformed cultured cells. The apoptotic effect of Salermide is in part because of the reactivation of proapoptotic genes that are epigenetically repressed by Sirt1 exclusively in cancer cells.

E Lara et al. Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene. 2009 Feb 12;28(6):781-91.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology CNS Diabetes & Metabolism Epigenetics DNA-damage Response EC 3.5.1.98 SIRT

Potent inhibitor of SIRT1 and SIRT2

Chemical name

N-(3-((2-Hydroxynaphthalen-1-yl)methyleneamino)phenyl)-2-phenylpropanamide

Parent CAS No.

[1105698-15-4]

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